Hadassah

Age-Related Macular Degeneration

Age-Related Macular Degeneration (AMD)  is a progressive disease where the macula —the cells at the central portion of the retina— deteriorates. The macula is responsible for focusing central vision, controlling our ability to read, drive, recognize faces and colors, and see fine details.

With macular degeneration, images are not received correctly. In the early stages of the disease, vision is not affected; however, as the disease progresses, people experience wavy or blurred vision, and, if the condition continues to worsen, central vision may be completely lost. There are two types of Age-Related Macular Degeneration: dry (atrophic) and wet (neovascular or exudative).

RESEARCH

One of the most promising areas of research with human embryonic stem cells (hESCs) is the collaborative work of Prof. Eyal Banin, Director of Hadassah Medical Organization’s Center for Retinal and Macular Degeneration, and Prof. Benjamin Reubinoff, Director of HMO’s Human Embryonic Stem Cell Research Center.Their research, which has focused on the dry form of the disease, is aimed at halting age-related macular degeneration (AMD).

Since age-related macular degeneration is caused by dysfunction in cells of the retina, called retinal pigment epithelium (RPE) cells, bolstering and replacing the failing cells has the potential to slow progression of the disease. Once the HMO team identified the necessary conditions for hESCs to become RPE cells in the laboratory, they were able to produce cells that are practically identical to those in the human eye.

Then the research team transplanted the cells into a rodent model with retinal disease and found that the cells significantly rescued the retina’s structure and ability to function.



NEXT STEPS:

  • Additional clinical trials using stem cells to slow, and potentially reverse, the progression of age-related macular degeneration.

With the aging baby boomer population, the diagnosis of age-related macular degeneration will rise exponentially.

GENDER EQUITY:

Worldwide, medical research disproportionately focuses on men – leading to misdiagnosis and compromised care for women. Join Hadassah and advocate for gender equity in medical research (GEM). Learn more at hadassah.org/GEM

THE POWER IS IN YOUR HANDS

DONATE TODAY. SAVE LIVES TOMORROW.

News & Stories

alt_text

Wednesday, May 13 2015

Israeli Biotech Co. Receives Major Grant to Further Develop Treatment for AMD

To further develop its world-first, animal product-free stem cell treatment for age-related...

READ MORE ›
alt_text

Thursday, Nov 6 2014

Clinical Trial of Hadassah-Developed Stem Cell Treatment for Macular Degeneration Gets Go-Ahead from FDA

“This is a significant milestone for our company and in the broader development of therapies...

READ MORE ›

Thursday, Dec 15 2011

Success of Clinical Trial Brings Researchers Closer to a Cure for Blindness

Researchers at the Hadassah University Medical Center have completed a clinical trial which has...

READ MORE ›

Wednesday, Aug 8 2012

Cell Cure Neurosciences Receives Grant of $1.33 Million From Israel's Office of the Chief Scientist

Cell Cure Neurosciences Ltd., whose Chief Scientific Officer is Hadassah University Medical...

READ MORE ›

See More News

Contact Us

40 Wall Street

New York, NY 10005

support@hadassah.org

More ›

Membership Questions

membership@hadassah.org

(800) 664-5646

Donation Questions

donorservices@hadassah.org

(800) 928-0685

Missions Department

missions@hadassah.org

(800) 237-1517

Show More