Hadassah

Conquering Brain Tumors at the Molecular Level

Monday, Dec 9 2013

For Regina Golan-Gerstl, a postdoctoral fellow at the Hadassah-Hebrew University School of Medicine, the fight against brain cancer has been close-up and personal: her mother died of the disease. She has now identified a genetic protein that is directly implicated in the development of the most prevalent brain cancer--glioblastoma.

Initially working in the specialty of pulmonology with Senior Hadassah Prof. Raphael Breuer, researching how cells communicate with one another, Dr. Golan-Gerstl switched to studying brain cancer when her mother became ill.

There is a mechanism called "splicing," she says, where elements of RNA (ribonucleic acid) are cut and recombined like sections of movie film. When a person is sick, Dr. Golan-Gerstl explains, the splicing mechanism doesn't work in the same way. An alternative splicing occurs, thanks to a genetic protein which becomes an activist in the development of cancer. She and her team have found that when the action of this gene is turned off, tumors in mice decrease in size. Dr. Golan-Gerstl adds that their first success has been with brain cancer.

Further investigation is taking place with other metastatic cancers, such as breast cancer. Tackling the problem with colleagues in Hadassah's Neuro-Oncology Department, Dr. Golan-Gerstl relates that they are "working on shutting it down at a molecular level."

Michael Klipper, Chair of Voices Against Brain Cancer, an organization dedicated to brain cancer research and advocacy, comments on the organization's website that "this discovery is comforting for those who are and who have been affected by this horrible disease. For one, it shows them that there are dedicated scientists and researchers who are working around the clock to put an end to this horrible disease. And two, it gives them hope that there actually will one day be a cure for brain cancer."

Comments

No comments yet.
First Name
Email
Comment
Enter this word:

Related Stories

alt_text

Thursday, Sep 14 2017

Hadassah's Head of Emergency Medicine Springs to Action at Bar Mitzvah

Dr. Jacob (Koby) Assaf, head of Emergency Medicine at Hadassah Hospital Ein Kerem, was at a family Bar Mitzvah in a Jerusalem hotel when suddenly a 60-year-old man collapsed right next to him.

READ MORE ›
alt_text

Thursday, Sep 14 2017

Professor, Grandfather, and Cancer Survivor: A Hadassah Story

Following a consultation with Hadassah Endocrinologist and NET specialist Dr. Simona Glasberg, Prof. Bruins underwent numerous tests to determine the source and extent of penetration of this slow-developing type of cancer.

READ MORE ›
alt_text

Thursday, Sep 7 2017

Upgraded Sperm Bank Inaugurated at Hadassah-Mt. Scopus

A spacious, upgraded sperm bank and new laboratories have been inaugurated at Hadassah Hospital Mount Scopus.

READ MORE ›
alt_text

Thursday, Sep 7 2017

Study by Renowned Hadassah Neuropsychiatrist Featured in The Lancet

The work of Dr. Shahar Arzy, head of the Hadassah Medical Organization’s Neuropsychiatry Clinic and the Hadassah-Hebrew University Computational Neuropsychiatry Laboratory, is featured in the September 4, 2017 issue of The Lancet Psychiatry.

READ MORE ›

Donation Questions

donorservices@hadassah.org

(800) 928-0685

Membership Questions

membership@hadassah.org

(800) 664-5646

Missions Department

missions@hadassah.org

(800) 237-1517

Contact Us

40 Wall Street

New York, NY 10005

support@hadassah.org

More ›

Show More