Hadassah

Conquering Brain Tumors at the Molecular Level

Monday, Dec 9 2013

For Regina Golan-Gerstl, a postdoctoral fellow at the Hadassah-Hebrew University School of Medicine, the fight against brain cancer has been close-up and personal: her mother died of the disease. She has now identified a genetic protein that is directly implicated in the development of the most prevalent brain cancer--glioblastoma.

Initially working in the specialty of pulmonology with Senior Hadassah Prof. Raphael Breuer, researching how cells communicate with one another, Dr. Golan-Gerstl switched to studying brain cancer when her mother became ill.

There is a mechanism called "splicing," she says, where elements of RNA (ribonucleic acid) are cut and recombined like sections of movie film. When a person is sick, Dr. Golan-Gerstl explains, the splicing mechanism doesn't work in the same way. An alternative splicing occurs, thanks to a genetic protein which becomes an activist in the development of cancer. She and her team have found that when the action of this gene is turned off, tumors in mice decrease in size. Dr. Golan-Gerstl adds that their first success has been with brain cancer.

Further investigation is taking place with other metastatic cancers, such as breast cancer. Tackling the problem with colleagues in Hadassah's Neuro-Oncology Department, Dr. Golan-Gerstl relates that they are "working on shutting it down at a molecular level."

Michael Klipper, Chair of Voices Against Brain Cancer, an organization dedicated to brain cancer research and advocacy, comments on the organization's website that "this discovery is comforting for those who are and who have been affected by this horrible disease. For one, it shows them that there are dedicated scientists and researchers who are working around the clock to put an end to this horrible disease. And two, it gives them hope that there actually will one day be a cure for brain cancer."

Comments

No comments yet.
First Name
Email
Comment
Enter this word:

Related Stories

alt_text

Friday, Sep 23 2016

2016 Graduates from 19 Countries Celebrate Hadassah’s IMPH Program

Singing "It's a Wonderful Country" in Hebrew, wearing their native dress, the members of the 41st International Master of Public Health (IMPH) program of the Hadassah-Hebrew University Braun School of Public Health and Community Medicine celebrated their graduation.

READ MORE ›
alt_text

Monday, Sep 19 2016

Hadassah Hospital Treats Terror Victims After Stabbing Attacks

This last week has brought a burst of terror attacks.

READ MORE ›
alt_text

Thursday, Sep 15 2016

“Stunning Results” Continue with Hadassah’s Stem Cell Treatment to Reverse MS

The Hadassah Medical Center is continuing to receive positive findings with its Phase II clinical trial using its unique stem cell approach to stop the progression and reversing the disabilities of multiple sclerosis.

READ MORE ›
alt_text

Thursday, Sep 15 2016

2012 Hadassah Stage-Four Melanoma Patient Thankfully Healthy

"Doctors in Florida who pronounced me ‘soon-dead’ can't believe that I'm healthy today,” said Hadassah melanoma patient Stewart Greenberg.

READ MORE ›

Contact Us

40 Wall Street

New York, NY 10005

support@hadassah.org

More ›

Membership Questions

membership@hadassah.org

(800) 664-5646

Donation Questions

donorservices@hadassah.org

(800) 928-0685

Missions Department

missions@hadassah.org

(800) 237-1517

Show More