Hadassah

Conquering Brain Tumors at the Molecular Level

Monday, Dec 9 2013

For Regina Golan-Gerstl, a postdoctoral fellow at the Hadassah-Hebrew University School of Medicine, the fight against brain cancer has been close-up and personal: her mother died of the disease. She has now identified a genetic protein that is directly implicated in the development of the most prevalent brain cancer--glioblastoma.

Initially working in the specialty of pulmonology with Senior Hadassah Prof. Raphael Breuer, researching how cells communicate with one another, Dr. Golan-Gerstl switched to studying brain cancer when her mother became ill.

There is a mechanism called "splicing," she says, where elements of RNA (ribonucleic acid) are cut and recombined like sections of movie film. When a person is sick, Dr. Golan-Gerstl explains, the splicing mechanism doesn't work in the same way. An alternative splicing occurs, thanks to a genetic protein which becomes an activist in the development of cancer. She and her team have found that when the action of this gene is turned off, tumors in mice decrease in size. Dr. Golan-Gerstl adds that their first success has been with brain cancer.

Further investigation is taking place with other metastatic cancers, such as breast cancer. Tackling the problem with colleagues in Hadassah's Neuro-Oncology Department, Dr. Golan-Gerstl relates that they are "working on shutting it down at a molecular level."

Michael Klipper, Chair of Voices Against Brain Cancer, an organization dedicated to brain cancer research and advocacy, comments on the organization's website that "this discovery is comforting for those who are and who have been affected by this horrible disease. For one, it shows them that there are dedicated scientists and researchers who are working around the clock to put an end to this horrible disease. And two, it gives them hope that there actually will one day be a cure for brain cancer."

Comments

No comments yet.
First Name
Email
Comment
Enter this word:

Related Stories

alt_text

Tuesday, Jan 10 2017

From Locked Jaw to Osteoarthritis: Hadassah Discovery Leads to New Treatment

What began as a solution to locked jaw--temporomandibular joint (TMJ) disorder--has led to the creation of a novel non-opioid pharmaceutical candidate for the treatment of osteoarthritis pain, thanks to a Hadassah Medical Organization discovery and collaboration with colleagues at the Hebrew University and the Technion.

READ MORE ›
alt_text

Monday, Jan 9 2017

Soldiers Rushed to Hadassah After January 8th Terrorist Attack

On Sunday January 8, four soldiers were killed and 17 wounded, when a terrorist rammed his vehicle into them.

READ MORE ›
alt_text

Monday, Jan 9 2017

Prime Minister Netanyahu visits terror survivors at Hadassah Hospital

Prime Minister Benjamin Netanyahu and Health Minister Yaakov Litzman visited terror victims hospitalized at Hadassah Hospital Ein Kerem after a terrorist rammed his flatbed truck into a group of soldiers on an IDF cultural field trip in Jerusalem. Four were killed, and 11 patients underwent treatment at Hadassah hospitals: 9 at Ein Kerem and 2 at Mount Scopus.

READ MORE ›
alt_text

Friday, Jan 6 2017

World-First Newborn Intestinal Surgery Saves Baby Girl at Hadassah

A baby girl whose intestines formed outside of her abdomen was saved by a world-first surgical procedure following her birth at Hadassah Hospital Ein Kerem.

READ MORE ›

Donation Questions

donorservices@hadassah.org

(800) 928-0685

Membership Questions

membership@hadassah.org

(800) 664-5646

Missions Department

missions@hadassah.org

(800) 237-1517

Contact Us

40 Wall Street

New York, NY 10005

support@hadassah.org

More ›

Show More