Hadassah

Drug Company Collaborates with Hadassah Liver Specialist in Fighting Liver Disease

Wednesday, Jan 10 2018

Illustration of the positive impact of Namodenoson, as compared to treatment of animals with a placebo (“vehicle”)

Dr. Rifaat Safadi, head of the Hadassah Medical Organization’s Liver Unit, in its Institute of Gastroenterology and Liver Diseases, is collaborating with Can-Fite BioPharma Ltd. to explore further the healing effects of a new drug that has proven in preclinical studies to mitigate inflammatory diseases of the liver, such as NASH (non-alcoholic steatohepatitis).

The new drug called Namodenoson, Dr. Safadi says, “is unique among today’s NASH drugs under development due to its excellent safety profile and the positive effect on steatosis (accumulation of fat in the liver), inflammation, and fibrosis (liver scarring, which results from dying of liver cells, also referred to as ballooning).”  Improvement in these parameters translates into a significant anti-NASH effect.

Namodenoson has been granted Orphan Drug Designation in the United States and Europe and Fast Track Designation as a second-line treatment for hepatocellular cancer by the United States Food and Drug Administration. It has the potential to be effective in treating other cancers, including colon and prostate cancer, as well as melanoma.

Can-Fite has initiated enrollment for a Phase II study with Namodenoson in NASH and NAFLD (non-alcoholic fatty liver disease) patients who show evidence of active inflammation. The focus will be on measuring the drug’s anti-inflammatory effect and its success in reducing fat in the liver.

A prolific researcher, renowned for his work with NASH, Dr. Safadi is also a member of Can-Fite’s Clinical Advisory Board. “We are privileged to work with Dr. Safadi to further study and advance the drug’s mechanism of action,” notes Pnina Fishman, PhD, Founder and Chief Executive Officer of Can-Fite.

Learn more about the Hadassah Medical Organization.

Comments

No comments yet.
First Name
Email
Comment
Enter this word:

Related Stories

alt_text

Monday, Oct 15 2018

Hadassah Dedicates Irma and Paul Milstein Heart Center at Hadassah Hospital Ein Kerem News Release

Hadassah unveiled the Irma and Paul Milstein Heart Center at Hadassah Hospital Ein Kerem on Friday, October 12th in Jerusalem, announced Ellen Hershkin, National President, Hadassah, the Women’s Zionist Organization of America, Inc.

READ MORE ›
alt_text

Friday, Oct 12 2018

New Zealand Scholarship Winner Comes to Hadassah Hospital

Describing it as a “life-changing experience,” Dinithi Seneviratne, a New Zealand health care professional, recently spent several weeks as an observer in the Pediatric Emergency Department at Hadassah Hospital in Ein Kerem, Jerusalem.

READ MORE ›
alt_text

Thursday, Oct 4 2018

Hadassah Receives $4.75M Grant from Helmsley Charitable Trust to Expand New Pediatric Bone Marrow Transplant (BMT) Unit

The Helmsley Charitable Trust has awarded a $4.75M grant to the Hadassah Medical Organization (HMO) in Israel to expand its Pediatric Bone Marrow Transplant (BMT) Unit, announced Ellen Hershkin, National President, Hadassah, The Women’s Zionist Organization of America, Inc. (HWZOA).

READ MORE ›
alt_text

Friday, Sep 28 2018

Hadassah Saves Mom and Delivers Her Baby in the Intensive Care Unit

A 32-year-old Palestinian woman in her third trimester of pregnancy developed blood clots and bruises and began to feel weak. Her local physicians were puzzled and recommended that she consult experts at the Hadassah Medical Organization in Jerusalem.

READ MORE ›

Donation Questions

donorservices@hadassah.org

(800) 928-0685

Membership Questions

membership@hadassah.org

(800) 664-5646

Missions Department

missions@hadassah.org

(800) 237-1517

Contact Us

40 Wall Street

New York, NY 10005

support@hadassah.org

More ›

Show More