Hadassah

Hadassah and Boston Cardiologists Identify Factor Which Exacerbates Heart Failure

Thursday, Sep 27 2012

In a series of experiments, Dr. Ronen Beeri, Director of the Cardiovascular Research Center at the Hadassah Medical Center, and Dr. Robert Levine, Senior Physician at Massachusetts General Hospital in Boston, have demonstrated that mitral regurgitation augments the remodeling process occurring after a myocardial infraction which, in turn, exacerbates further heart failure.

They have also discovered that repairing the mitral regurgitation early enough may reverse these deleterious processes, while delayed repair may not. The two physicians have now begun to explore the cellular processes which cause the individual cells to fail. In what may hold promise for the future, they have utilized gene therapy techniques in a sheep model of heart failure to implant a gene for the Sarcoplasmic reticulum Ca (+2)-ATPase ( SERCA2a), which controls a key process in the cell's calcium signaling. The sheep which underwent gene therapy had upregulated levels of SERCA2a, which led to better function and lesser remodeling. They exhibited improved contractility, smaller heart volumes, and activation of cellular pathways that lead to better heart compensation.

Comments

No comments yet.
First Name
Email
Comment
Enter this word:

Related Stories

alt_text

Wednesday, Mar 1 2017

Closing the Global Gap in Cystic Fibrosis Treatment: Hadassah Shares Expertise

With treatment advances in Cystic Fibrosis (CF) extending the duration and quality of life for many patients in developed countries, Hadassah CF specialists are reaching out to close the gap for CF patients in low-income countries.

READ MORE ›
alt_text

Wednesday, Mar 1 2017

How Well Are You Breathing? Hadassah Provides the Answer

Hundreds of people walking through the atrium of Hadassah Hospital Ein Kerem’s Sarah Wetsman Davidson Hospital Tower took advantage of the free screening to evaluate the quality of their breathing.

READ MORE ›
alt_text

Wednesday, Mar 1 2017

Groundbreaking Hadassah Lymphoma Study Identifies and Compares Risk Factors Among Palestinians and Jews

This is the first large study to examine medical history and environmental and lifestyle risk factors for B-cell non-Hodgkin lymphoma and its subtypes in these populations.

READ MORE ›
alt_text

Wednesday, Feb 22 2017

Hadassah Medical Organization Performs Israel’s First Spina Bifida Fetal Surgery To Lessen Crippling Spinal Damage

History was made at Hadassah Ein Kerem Hospital in Jerusalem on Thursday, February 9 when a team of Israeli surgeons successfully operated on a 5-month-old fetus using a new procedure that only three doctors in the world can perform, to alleviate some of the crippling effects of Spina Bifida.

READ MORE ›

Donation Questions

donorservices@hadassah.org

(800) 928-0685

Membership Questions

membership@hadassah.org

(800) 664-5646

Missions Department

missions@hadassah.org

(800) 237-1517

Contact Us

40 Wall Street

New York, NY 10005

support@hadassah.org

More ›

Show More