Hadassah and Boston Cardiologists Identify Factor Which Exacerbates Heart Failure

Thursday, Sep 27 2012

In a series of experiments, Dr. Ronen Beeri, Director of the Cardiovascular Research Center at the Hadassah Medical Center, and Dr. Robert Levine, Senior Physician at Massachusetts General Hospital in Boston, have demonstrated that mitral regurgitation augments the remodeling process occurring after a myocardial infraction which, in turn, exacerbates further heart failure.

They have also discovered that repairing the mitral regurgitation early enough may reverse these deleterious processes, while delayed repair may not. The two physicians have now begun to explore the cellular processes which cause the individual cells to fail. In what may hold promise for the future, they have utilized gene therapy techniques in a sheep model of heart failure to implant a gene for the Sarcoplasmic reticulum Ca (+2)-ATPase ( SERCA2a), which controls a key process in the cell's calcium signaling. The sheep which underwent gene therapy had upregulated levels of SERCA2a, which led to better function and lesser remodeling. They exhibited improved contractility, smaller heart volumes, and activation of cellular pathways that lead to better heart compensation.


No comments yet.
First Name
Enter this word:

Related Stories


Wednesday, Mar 14 2018

A Record Year for Transplants at Hadassah

The Hadassah Medical Organization completed the past year with a record number of transplants in its Transplantation Unit, one of the largest and most active in Israel.


Thursday, Mar 8 2018

Hadassah Physicians Travel to Mexico to Repair Cleft Palates

This week, a team of Hadassah physicians are performing surgery on children with cleft palates in Mexico. This is a part of the continuing impact that Hadassah is having on health in Mexico.


Thursday, Mar 8 2018

Hadassah Performs Rare Operation on Baby About to be Born

A baby suffering from a complex congenital disorder called Stickler Syndrome was delivered successfully following the performance by a Hadassah Medical Organization multidisciplinary team of a rare operation to unblock its air passages.


Thursday, Mar 1 2018

Rare Surgery Performed on Awake Newborn

A rare surgery to correct a complication in the digestive system of a newborn baby was performed at Hadassah Hospital Ein Kerem this week while the baby was awake and sucking sugar water during the procedure.


Donation Questions


(800) 928-0685

Membership Questions


(800) 664-5646

Missions Department


(800) 237-1517

Contact Us

40 Wall Street

New York, NY 10005


More ›

Show More