Hadassah and Boston Cardiologists Identify Factor Which Exacerbates Heart Failure

Thursday, Sep 27 2012

In a series of experiments, Dr. Ronen Beeri, Director of the Cardiovascular Research Center at the Hadassah Medical Center, and Dr. Robert Levine, Senior Physician at Massachusetts General Hospital in Boston, have demonstrated that mitral regurgitation augments the remodeling process occurring after a myocardial infraction which, in turn, exacerbates further heart failure.

They have also discovered that repairing the mitral regurgitation early enough may reverse these deleterious processes, while delayed repair may not. The two physicians have now begun to explore the cellular processes which cause the individual cells to fail. In what may hold promise for the future, they have utilized gene therapy techniques in a sheep model of heart failure to implant a gene for the Sarcoplasmic reticulum Ca (+2)-ATPase ( SERCA2a), which controls a key process in the cell's calcium signaling. The sheep which underwent gene therapy had upregulated levels of SERCA2a, which led to better function and lesser remodeling. They exhibited improved contractility, smaller heart volumes, and activation of cellular pathways that lead to better heart compensation.


No comments yet.
First Name
Enter this word:

Related Stories


Wednesday, Oct 26 2016

Granny's Garden Dedication

Estelle Siegel of Philadelphia and Palm Beach Gardens, Florida dreamed of creating an outdoor place of beauty and comfort for patients and their families who were receiving medical care.


Wednesday, Oct 19 2016

Caryn Andrews: Hadassah Nurse Practitioner on a Mission

Nurse Practitioner Caryn Scheinberg Andrews, who immigrated to Israel from Baltimore, Maryland in 2011 and is a lecturer in the Hadassah-Hebrew University Henrietta Szold School of Nursing, is on a personal mission: to fortify Israel's health delivery capacity by helping to create a cadre of advanced practice nurses.


Wednesday, Oct 5 2016

Russian Children Travel to Hadassah to be Treated For a Rare Disease

To date, Hadassah has treated over 14 Russian children, saving their sight and hearing and offering them the opportunity to grow up and live normal lives.


Wednesday, Sep 28 2016

Hadassah Medical Organization Goes on High Alert for Peres Funeral

Thousands of visitors, including high profile dignitaries, are expected to arrive in Jerusalem for the funeral of past Prime Minister and President Shimon Peres, who will be laid to rest on Friday, September 30.


Contact Us

40 Wall Street

New York, NY 10005


More ›

Membership Questions


(800) 664-5646

Donation Questions


(800) 928-0685

Missions Department


(800) 237-1517

Show More