Hadassah

Hadassah and Boston Cardiologists Identify Factor Which Exacerbates Heart Failure

Thursday, Sep 27 2012

In a series of experiments, Dr. Ronen Beeri, Director of the Cardiovascular Research Center at the Hadassah Medical Center, and Dr. Robert Levine, Senior Physician at Massachusetts General Hospital in Boston, have demonstrated that mitral regurgitation augments the remodeling process occurring after a myocardial infraction which, in turn, exacerbates further heart failure.

They have also discovered that repairing the mitral regurgitation early enough may reverse these deleterious processes, while delayed repair may not. The two physicians have now begun to explore the cellular processes which cause the individual cells to fail. In what may hold promise for the future, they have utilized gene therapy techniques in a sheep model of heart failure to implant a gene for the Sarcoplasmic reticulum Ca (+2)-ATPase ( SERCA2a), which controls a key process in the cell's calcium signaling. The sheep which underwent gene therapy had upregulated levels of SERCA2a, which led to better function and lesser remodeling. They exhibited improved contractility, smaller heart volumes, and activation of cellular pathways that lead to better heart compensation.

Comments

No comments yet.
First Name
Email
Comment
Enter this word:

Related Stories

alt_text

Thursday, Jul 13 2017

Hadassah Gives Gift of Hearing to Deaf Boy from Gaza

Mohammed, a youngster from Gaza, was born without the ability to hear. Thanks to Hadassah Hospital Ein Kerem’s sophisticated technology and treatment, Mohammed is no longer deaf.

READ MORE ›
alt_text

Wednesday, Jul 12 2017

The Woman Behind the Trailblazing Treatment

Hadassah’s Prof. Michal Lotem, a trailblazer in melanoma research and healing, is treating her patients with a personalized protocol that only a handful of oncology centers around the globe are able to offer.

READ MORE ›
alt_text

Wednesday, Jul 12 2017

Medical Clown Nehama’s Blog, Chapter Three

In this blog, I bring you a lyrical story by Medical Clown Shiri Breuer, entitled “Miracles Do Happen.”

READ MORE ›
alt_text

Monday, Jul 10 2017

HMO Docs Perform Rare In-Utero Heart Surgery

In a risky and delicate in-utero procedure performed for the first time in Israel, an interdisciplinary team of Hadassah Medical Organization doctors saved the life of a 28-week-old fetus with a severe heart defect.

READ MORE ›

Donation Questions

donorservices@hadassah.org

(800) 928-0685

Membership Questions

membership@hadassah.org

(800) 664-5646

Missions Department

missions@hadassah.org

(800) 237-1517

Contact Us

40 Wall Street

New York, NY 10005

support@hadassah.org

More ›

Show More