Hadassah

Hadassah and Boston Cardiologists Identify Factor Which Exacerbates Heart Failure

Thursday, Sep 27 2012

In a series of experiments, Dr. Ronen Beeri, Director of the Cardiovascular Research Center at the Hadassah Medical Center, and Dr. Robert Levine, Senior Physician at Massachusetts General Hospital in Boston, have demonstrated that mitral regurgitation augments the remodeling process occurring after a myocardial infraction which, in turn, exacerbates further heart failure.

They have also discovered that repairing the mitral regurgitation early enough may reverse these deleterious processes, while delayed repair may not. The two physicians have now begun to explore the cellular processes which cause the individual cells to fail. In what may hold promise for the future, they have utilized gene therapy techniques in a sheep model of heart failure to implant a gene for the Sarcoplasmic reticulum Ca (+2)-ATPase ( SERCA2a), which controls a key process in the cell's calcium signaling. The sheep which underwent gene therapy had upregulated levels of SERCA2a, which led to better function and lesser remodeling. They exhibited improved contractility, smaller heart volumes, and activation of cellular pathways that lead to better heart compensation.

Comments

No comments yet.
First Name
Email
Comment
Enter this word:

Related Stories

Friday, Apr 28 2017

Surgeons Perform World’s First-Ever Dual Robotic Surgery
 at Jerusalem’s Hadassah Hospital

The world’s first-of-its-kind dual robotic surgery was performed on April 23 at Hadassah Hospital Ein Kerem in Jerusalem, announced National President Ellen Hershkin of Hadassah, the Women’s Zionist Organization of America, Inc. (HWZOA).

READ MORE ›
alt_text

Tuesday, Apr 25 2017

Hadassah Performs World First Two-Robot Repair of Complex Spinal Break

Suffering six broken vertebrae and leg fractures in two places, Mr. Schwartz was brought to the underground hybrid operating room in Hadassah Hospital Ein Kerem’s Sarah Wetsman Davidson Hospital Tower. “In the hybrid room are two robots,” explains Prof. Meir Liebergall, head of Hadassah’s Orthopedic Department. “The more innovative of the two is the Zeego...

READ MORE ›
alt_text

Monday, Apr 24 2017

Hadassah Surgeon Saves Hands of Border Guards

It was cold and dark outside the Lions Gate of the Old City at 4 am on March 13, the day on which Jerusalem citizens were celebrating Purim.

READ MORE ›
alt_text

Monday, Apr 24 2017

Hadassah’s New Home Away from Home for Parents with Ill Children

Hadassah Hospital Mount Scopus now houses Israel’s first Pediatric Palliative and Supportive Care Center, a home away from home for parents and their children with chronic or terminal diseases.

READ MORE ›

Donation Questions

donorservices@hadassah.org

(800) 928-0685

Membership Questions

membership@hadassah.org

(800) 664-5646

Missions Department

missions@hadassah.org

(800) 237-1517

Contact Us

40 Wall Street

New York, NY 10005

support@hadassah.org

More ›

Show More