Hadassah

Hadassah Breakthrough Identifies Carriers of Lynch Syndrome Mutation That Causes Colon and Gynecological Cancers

Friday, Dec 19 2014

While many people know about the BRCA gene mutations that can lead to the development of breast cancer--even more so since renowned actress Angelina Jolie publicized the importance of being tested-- fewer people know about Lynch Syndrome. Yet, testing for this mutation can prevent colon, endometrial, and ovarian cancer and enable early detection of pancreatic and urinary tract cancer, a Hadassah Medical Center research team reveals.

“I'm so passionate about this because I know this testing can save lives,” says Dr. Yael Goldberg, a Hadassah Medical Center oncologist and specialist in oncogenetics who led the research team. “Colon cancer can be prevented or detected early in around 90 percent of carriers of the mutation who do the correct follow-up procedures.”

Dr. Goldberg emphasizes: “If you have colon cancer or endometrial cancer in your family or if your colonoscopy turns up five or more polyps, you should be tested for Lynch Syndrome.  It can literally save your life.” She further notes that our knowledge of typical founder mutations in specified ethnic groups, such as Ashkenazi Jews and Jews from Iran, the former Soviet Republic of Georgia, and Afghanistan, makes testing for the mutation simpler and quicker.

While the prevalence of the Lynch mutation is not as high as the BRCA one in either the general population or the Jewish population, it is significant: estimated as 1:370. In the United States, however, fewer than five percent of those who are at high risk actually get tested. In Israel, mainly due to lobbying by the collaborative research team from Hadassah, Ichilov Hospital/Tel Aviv Sourasky Medical Center, and Beilinson Hospital/Rabin Medical Center, the Israeli health care system will be covering this test as of January 2015.

The overall lifetime risk of developing the cancers associated with Lynch Syndrome has reached 80 percent. Furthermore, when both parents carry the gene mutation, there is a l:4 risk for having a child who carries mutations in both copies of the gene. This can result in a very morbid condition called C-MMRD, Dr. Goldberg reports, where the child is at high risk for a horrendous cluster of deadly cancers.  As with Tay Sachs disease, she brings out, “awareness and screening for Lynch Syndrome could help avoid this condition.”

Comments

No comments yet.
First Name
Email
Comment
Enter this word:

Related Stories

alt_text

Wednesday, Feb 22 2017

Hadassah Medical Organization Performs Israel’s First Spina Bifida Fetal Surgery To Lessen Crippling Spinal Damage

History was made at Hadassah Ein Kerem Hospital in Jerusalem on Thursday, February 9 when a team of Israeli surgeons successfully operated on a 5-month-old fetus using a new procedure that only three doctors in the world can perform, to alleviate some of the crippling effects of Spina Bifida.

READ MORE ›
alt_text

Tuesday, Feb 21 2017

Hadassah Cardiologists Publicize Israel’s Dramatic Decrease in Cardiovascular Death

Prof. Emeritus Mervyn Gotsman and Prof. Israel Gotsman of Hadassah Hospital’s Heart Institute have coauthored an article which appeared in the European Heart Journal, highlighting the fact that “between 1998 and 2012, mortality from cardiovascular disease in Israel has fallen from 162 to 80 per 100,000 residents--a decrease of 50 percent.”

READ MORE ›
alt_text

Tuesday, Feb 21 2017

Ambassadors of Health for Heart Smart Living: A Unique Hadassah Program

Knowing that the workplace is where people spend vast quantities of time, the Hadassah Medical Organization’s Linda Joy Pollin Cardiovascular Wellness Center for Women launched a unique course to encourage heart healthy living—during the work day.

READ MORE ›
alt_text

Tuesday, Feb 21 2017

Hadassah Brings Health Empowerment to East Jerusalem

The increased incidence of diabetes in the Arab community, as well as the 60 percent higher rate of cardiovascular mortality among Arab women led the Hadassah Medical Organization’s Linda Joy Pollin Cardiovascular Wellness Center for Women to develop a community-based program to cultivate leadership that embraces and advocates for healthy living which will reduce diabetes in this population.

READ MORE ›

Donation Questions

donorservices@hadassah.org

(800) 928-0685

Membership Questions

membership@hadassah.org

(800) 664-5646

Missions Department

missions@hadassah.org

(800) 237-1517

Contact Us

40 Wall Street

New York, NY 10005

support@hadassah.org

More ›

Show More