Hadassah

Hadassah Cures Mumbai Child of Thalassemia with Cutting-Edge Diagnosis

Thursday, Mar 26 2015

One day, Prof. Ariel Revel, head of the Ovum Donation and Fertility Preservation Program at the Hadassah Medical Center, was contacted by a professor from Mumbai, who had a one-year-old daughter with Thalassemia, an inherited blood disorder that threatened the quality of her life. Thanks to Hadassah’s state-of-the-art multi-stage intervention—including Pre-Implantation Genetic Diagnosis (PGD), In-vitro Fertilization (IVF), and a bone marrow transplant—that little girl is now Thalassemia-free.

Thalassemia, characterized by the abnormal formation of hemoglobin, is particularly found in people of Mediterranean origin and is prevalent in Israel. In Thalassemia major, the abnormality results in improper oxygen transport and the destruction of red blood cells, causing significant complications such as bone deformities and heart disease. In addition, sufferers often need blood transfusions on a regular basis, resulting in iron overload.

If a person is only a carrier of the disorder (having only one recessive gene for it), the result is mild anemia. If both parents carry the recessive gene, 25 percent of their children will be born with Thalassemia major.

A bone marrow transplant can change the composition of the blood and the fate of a child born with Thalassemia major. The bone marrow donor, however, needs to be close in age, race, and ethnicity to the child. In addition, the donor must have matching human leukocyte antigen (HLA), a particular aspect of the blood type. After researching world databases, the father was told his best option was to have another child, who would hopefully be healthy and a compatible donor for the sister.

Thanks to PGD, this medical intervention is possible. Through PGD, physicians can check the embryos to see if the child will be healthy and an HLA match. When an embryo meeting the qualifications is found, it is implanted into the uterus and the pregnancy proceeds as usual. There are only a few countries in the world that perform these diagnostic tests and Israel is one of them, Prof. Revel said. The Mumbai couple chose to come to Hadassah.

Following ovarian stimulation, Prof. Revel and his team removed 19 eggs from the mother and fertilized them. They examined all resulting embryos through PGD and found two that were an HLA match; however, one was thalassemic. The other, fortunately, was heterozygous for the gene, like the parents, and therefore had only Thalassemia minor. The doctors transferred the embryo to the patient's uterus and a normal pregnancy was launched.

Nine months later, a healthy baby boy was born. When he was one year old, his bone marrow was extracted for transplantation into his sister, making her a healthy three-year-old girl.

Prof. Revel was able to visit the family during a recent professional trip to India. “I had the pleasure of seeing for myself the fruits of our endeavors,” he said. “What a great feeling!”

Comments

No comments yet.
First Name
Email
Comment
Enter this word:

Related Stories

alt_text

Tuesday, May 23 2017

First Ladies Melania Trump and Sara Netanyahu Visit Hadassah Hospital

Please share our pride in Hadassah Hospital, singled out by the Israeli government to showcase the nation’s top-quality medicine, top doctors, and innovative medical research. First Lady Melania Trump and First Lady Sara Netanyahu visited Hadassah Hospital Ein Kerem on May 22...

READ MORE ›
alt_text

Wednesday, May 10 2017

Hadassah’s Melanoma Maven Featured in Hadassah Magazine

Metastatic melanoma is typically fatal, but Hadassah Hospital’s Prof. Michal Lotem, a world-renowned, cutting-edge physician/scientist, is trailblazing new treatments that are being watched around the globe.

READ MORE ›
alt_text

Monday, May 1 2017

Hadassah Surgeon to Light Torch at Jerusalem Independence Day Ceremony

Meet Prof. Ahmed Eid of Hadassah Hospital, who will light the torch at Jerusalem's Independence Day Ceremony, in honor of the city’s doctors who tirelessly work to save lives and improve the quality of life of men, women and children.

READ MORE ›

Friday, Apr 28 2017

Surgeons Perform World’s First-Ever Dual Robotic Surgery
 at Jerusalem’s Hadassah Hospital

The world’s first-of-its-kind dual robotic surgery was performed on April 23 at Hadassah Hospital Ein Kerem in Jerusalem, announced National President Ellen Hershkin of Hadassah, the Women’s Zionist Organization of America, Inc. (HWZOA).

READ MORE ›

Donation Questions

donorservices@hadassah.org

(800) 928-0685

Membership Questions

membership@hadassah.org

(800) 664-5646

Missions Department

missions@hadassah.org

(800) 237-1517

Contact Us

40 Wall Street

New York, NY 10005

support@hadassah.org

More ›

Show More