Hadassah

Hadassah Ophthalmology Department Research Highlighted by JAMA

Tuesday, Jun 12 2018

Thanking the Hadassah Medical Organization’s researchers for their ”excellent submission” to JAMA Ophthalmology regardinga multi-center international study of the variable effectiveness of treatment for neovascular age-related macular degeneration (nAMD),the editors explained that their article was one of just a few from 12 JAMA on-line journals to be highlighted in The JAMA Network Reader this weekend.

The Reader is available free to everyone around the world at http://app.jamanetwork.com.

Prof. Itay Chowers, head of Hadassah’s Department of Ophthalmology, and Michelle Grunin, a PhD student of his at the time, conducted this study in collaboration with colleagues in Australia, Canada, Germany, the Netherlands, Northern Ireland, Norway, Switzerland, United Kingdom, and the United States. Together, they identified genetic factors that are associated with variability in response to a particular type of therapy for patients with nAMD, where abnormally high levels of vascular endothelial growth factor (VEGF) are secreted in the eyes, promoting the growth of new abnormal blood vessels. Anti-VEGF injection therapy blocks this growth.

The authors’ findings led them to propose that “there is a limited contribution of common genetic variants to variability in nAMD treatment response. Our results suggest that rare protein-altering variants in the C10orf88 and UNC93B1 genes are associated with a worse response to anti-VEGF therapy in patients with nAMD, but these results require further validation in other cohorts.”

Read the full article in JAMA Ophthalmology.

Comments

No comments yet.
First Name
Email
Comment
Enter this word:

Related Stories

alt_text

Thursday, May 16 2019

First of Its Kind in Israel: Cardiac Catheterization at Hadassah on Under Two-Pound Baby

A cardiac catheterization, the first of its kind in Israel, was successfully performed this week at Hadassah Hospital Ein Kerem on a fragile premature infant, weighing under two pounds.

READ MORE ›
alt_text

Wednesday, May 15 2019

How Much Do You Know About Your Liver and Hadassah’s Life-Saving Liver Treatments?

Three pounds of reddish-brown tissue tucked under the diaphragm, your liver churns out over 1,000 different types of enzymes to help you digest food, store energy, and wash out toxins

READ MORE ›
alt_text

Monday, May 13 2019

Grappling with Life Post-Trauma: Hadassah Therapist Offers Advice

As we return to normal life in the aftermath of terror attacks, whether in synagogues, churches, or other settings in our local communities, how do we cope?

READ MORE ›
alt_text

Thursday, May 9 2019

When Gender Is Ambiguous

Under the cover of darkness, an Arab family left Gaza for Hadassah Hospital Ein Kerem. Little Noor would return as little Ahmed.

READ MORE ›

Donation Questions

donorservices@hadassah.org

(800) 928-0685

Membership Questions

membership@hadassah.org

(800) 664-5646

Missions Department

missions@hadassah.org

(800) 237-1517

Contact Us

40 Wall Street

New York, NY 10005

support@hadassah.org

More ›

Show More