Hadassah

Hadassah Researchers Identify Connection Between National Killer Cell and Cirrhosis

Tuesday, Mar 19 2013

Researchers at the Hadassah University Medical Center have discovered that over expression of an immune system Natural Killer (NK) cell called Neuroligin 4 can trigger cirrhosis of the liver by preventing the body from combating scarring. The Hadassah study compared blood samples from dozens of patients with cirrhosis to those of a healthy control group. "In their healthy form, the Neuroligin cells kill the scar-tissue cells," reports Prof. Rifaat Safadi, head of Hadassah's Liver Unit and this study. In the over expression scenario, he explains, "a mechanism is put into operation that keeps the cells from doing their unscarring work."

Several years ago, the same research team found that intact NK cells are good for the liver and prevent cirrhosis. The finding was published in the February 2006 issue of The Journal of Hepatology and also reported by a group of researchers at the National Institutes of Health in the United States. Next, Hadassah's researchers plan to investigate whether mutations of Neuroligin 4 also increase the risk of cirrhosis.

Hadasit, Hadassah's Technology Transfer Company, has already patented Neuroligin 4 in hopes of using it to develop treatments to fend off liver disease.


Read the story in Haaretz here>>

Comments

No comments yet.
First Name
Email
Comment
Enter this word:

Related Stories

alt_text

Wednesday, Nov 14 2018

A Hassidic Mother’s Promise to Donate a Kidney: Mission Accomplished

A young girl named Esti had a best friend named Tali whose father had kidney disease. He passed away before a kidney transplant could save his life.

READ MORE ›
alt_text

Friday, Nov 9 2018

Children with Low Vision Receive Unique Care at Hadassah

“The vision of world-renowned Prof. Isaac Caesar Michaelson, former Director of the Hadassah Medical Organization’s Department of Ophthalmology, of creating in 1973 The Jerusalem Institute for the Prevention of Blindness still amazes me,” says Dr. Claudia Yahalom, current head of the renamed Michaelson Institute for Rehabilitation of Vision at Hadassah Hospital Ein Kerem.

READ MORE ›
alt_text

Tuesday, Nov 6 2018

Hadassah Staff Saves Seven-Year-Old From Deadly Scorpion Bite

The intensity of his cry alerted Elisha Alush’s parents that something serious had happened to their seven-year-old. He ran in from the backyard of their home near Jericho, north of Jerusalem, screaming, “My foot, my foot.” And then he lost consciousness.

READ MORE ›
alt_text

Thursday, Nov 1 2018

Hadassah Saves Soccer Fan’s Life in Newly Inaugurated Heart Center

Mickey Peretz, age 36, began his evening at a Beitar Jerusalem soccer game. Little did he know that he would end the evening being the first patient to receive a life-saving heart catheterization in Hadassah Hospital Ein Kerem’s brand new Irma and Paul Milstein Heart Center.

READ MORE ›

Donation Questions

donorservices@hadassah.org

(800) 928-0685

Membership Questions

membership@hadassah.org

(800) 664-5646

Missions Department

missions@hadassah.org

(800) 237-1517

Contact Us

40 Wall Street

New York, NY 10005

support@hadassah.org

More ›

Show More