Hadassah

Initiated in Israel, Clinical Trial for Innovative Pancreatic Cancer Treatment Expands to United States

Saturday, Dec 1 2012

A clinical trial with TL-118--a new treatment for metastatic pancreatic cancer--that has been ongoing at the Hadassah University Medical Center and three other oncology centers in Israel, has been expanded to the United States.

TL-118. produced by Tiltan Pharma Ltd., belongs to the family of angiogenesis-inhibiting drugs, which means it inhibits new blood vessel formation in tumors and thus cuts off their blood supply and growth. Angiogenesis, the process by which new blood vessels are formed, is a hallmark capability of cancer cells. Anti-angiogenic therapy has, therefore, emerged as a most promising strategy with solid tumors, which rely on aggressive angiogenesis for their growth.

The new United States trial will be conducted at White Plains (NY) Hospital, and will include patients who have been newly diagnosed with metastatic pancreatic cancer and not yet treated with any chemotherapy. A control group will receive standard chemotherapy, while the treatment group will receive TL-118 in addition to chemotherapy.

Dr. Dan Costin, Co-Medical Director of the White Plains Hospital cancer program and Principal Investigator for the TL-118 study at White Plains Hospital, related: "We are happy to introduce this cutting-edge therapy to our pancreatic cancer patients. Unfortunately, metastatic pancreatic cancer is a disease with very poor prognosis and we are urgently seeking new solutions that might enhance survival."

TL-118 was initially tested in a mouse model of pancreatic cancer. In these pre-clinical studies, TL-118 monotherapy inhibited tumor growth significantly, as compared to the standard-of-care chemotherapy. Moreover, when TL-118 therapy was combined with standard-of-care chemotherapy, the tumors were eliminated in all the treated animals.

To date, over 100 cancer patients have been treated with TL-118 for up to four years, according to Tiltan Pharma, jointly owned by Yissum, the Hebrew University's Technology Transfer Company, and other investors from Israel and Canada.

Comments

No comments yet.
First Name
Email
Comment
Enter this word:

Related Stories

alt_text

Wednesday, Mar 22 2017

Marathon Runner Pays Tribute to Hadassah Medical Team

After successfully running in the 2017 Jerusalem Marathon, Gil Troy pays tribute to Prof. Meir Liebergall, Director of the Hadassah Medical Organization’s Orthopedic Surgery Department, and his medical team, who made this run possible.

READ MORE ›
alt_text

Wednesday, Mar 22 2017

Reversing the Odds with Technology and Expertise

It could be a young patient with a virulent flu. Or a man having a severe asthma attack. Or a pregnant woman with a complication of pregnancy.

READ MORE ›
alt_text

Wednesday, Mar 22 2017

Cypriot Health Minister Helps Save Israeli Patient

Whether it was a newborn baby with a severe heart defect or a pregnant woman with an unusual ectopic pregnancy, the Hadassah Medical Organization has been known to save the lives of Cypriot patients by helicoptering them to its hospital for complex emergency treatments. Recently, however, it was the Cypriot Health Minister who helped save the life of an Israeli patient.

READ MORE ›
alt_text

Wednesday, Mar 22 2017

Top-Tier Turkish Journalists Receive Inside View of Hadassah Hospital

A delegation of top-tier Turkish journalists, accompanied by representatives from the Israel Foreign Ministry, visited Hadassah Hospital Ein Kerem this month, marking the first time a high-level Turkish delegation has come to Israel since the new reconciliation agreement was signed between Israel and Turkey.

READ MORE ›

Donation Questions

donorservices@hadassah.org

(800) 928-0685

Membership Questions

membership@hadassah.org

(800) 664-5646

Missions Department

missions@hadassah.org

(800) 237-1517

Contact Us

40 Wall Street

New York, NY 10005

support@hadassah.org

More ›

Show More