Hadassah

Israeli Biotech Co. Receives Major Grant to Further Develop Treatment for AMD

Wednesday, May 13 2015

To further develop its world-first, animal product-free stem cell treatment for age-related macular degeneration (AMD), Israel’s Cell Cure Neurosciences Ltd. has received a 6.24 million shekel (approximately $1.6 million dollar) grant from Israel's Office of the Chief Scientist (OCS).

A clinical trial using this product was initiated in February at the Hadassah Medical Organization, whose Prof. Benjamin Reubinoff, Chief Scientific Officer of Cell Cure and Director of Hadassah's Human Embryonic Stem Cell Research Center, and Prof. Eyal Banin, head of the Center for Retinal and Macular Degeneration, were instrumental in its development. The product, called OpRegen®, is a retinal pigment epithelial (RPE) cell formulation derived from human embryonic stem cells (hESCs), characterized by high purity and potency.

"We thank the Israel Office of the Chief Scientist for its commitment to innovation and for continuing support of Cell Cure and its development of a cell therapy-based treatment for a major disease of aging," said Charles Irving, PhD, Chief Executive Officer of Cell Cure.

"I join with Dr. Irving in thanking the OCS for its generous support in advancing pluripotent stem cell research into clinical applications," Prof. Reubinoff related.

The Phase I/IIa study of OpRegen® has been designed to provide preliminary, objective, functional and structural data on this cell transplantation's ability to slow the progression of geographic atrophy (dry-AMD), in addition to safety data. Dry-AMD severely impacts the quality of life of the elderly and there is as yet no approved therapy.

The clinical trial, involving four groups of patients, will evaluate three different dose regimens. Cell Cure expects to report interim data from the cohorts in the coming months. Details of the trial are available at https://clinicaltrials.gov/ct2/show/NCT02286089?term=OpRegen&rank=1

Dry AMD is the leading cause of visual impairment and blindness among the elderly in the US and other developed countries. While treatment options exist for the treatment of the wet form of AMD, 90 percent of all patients with AMD have the dry form. As Cell Cure's website explains: "The root cause of dry-AMD is believed to be the dysfunction of RPE cells. Therefore, one of the most exciting new therapeutic strategies for dry-AMD is the transplantation of healthy young RPE cells to support and replace those lost with age. Pluripotent stem cells, such as hESCs, can potentially provide a means of manufacturing such healthy RPE cells on an industrial scale."

Comments

No comments yet.
First Name
Email
Comment
Enter this word:

Related Stories

alt_text

Thursday, Feb 7 2019

Six Miscarriages, a Severe Liver Disease, and a Dream

Oshrat Ohana Nagar was a busy newspaper journalist, a self-proclaimed workaholic, and a mother of two children. Shortly after the birth of her second child, however, she began to experience pain throughout her body.

READ MORE ›
alt_text

Wednesday, Feb 6 2019

Hadassah Hematologist Dina Ben-Yehuda: Healer, Researcher, Mentor, and Dean

During this age of big data and artificial intelligence, Prof. Dina Ben-Yehuda, head of the Hadassah Medical Organization’s Department of Hematology and now also the first female dean of the Hadassah-Hebrew University School of Medicine, believes that the “role of physician as healer is more necessary for patients than ever.”

READ MORE ›
alt_text

Wednesday, Feb 6 2019

Hadassah Eye Specialists Take Their Expertise to Nursing Homes

Saving nursing home residents from the burden of commuting to the hospital for eye examinations, Hadassah Medical Organization ophthalmologists and optometrists have begun bringing their expertise to the seniors’ home setting.

READ MORE ›
alt_text

Monday, Feb 4 2019

Hadassah Breast Imaging Specialist Offers Perspective on Preventive Care

The most important adversary to breast cancer screening is fear, says Dr. Tamar Sella, head of the Marlene Greenebaum Multidisciplinary Diagnostic Breast Center at the Hadassah Medical Organization.

READ MORE ›

Donation Questions

donorservices@hadassah.org

(800) 928-0685

Membership Questions

membership@hadassah.org

(800) 664-5646

Missions Department

missions@hadassah.org

(800) 237-1517

Contact Us

40 Wall Street

New York, NY 10005

support@hadassah.org

More ›

Show More