Hadassah

Large Multinational Study Reveals Benefits of Dapagliflozin for Treatment of Diabetes

Thursday, Mar 21 2019

With 450 million adults worldwide suffering from diabetes today and an increase to more than 640 million expected by 2040, the need for a safe and effective treatment is ever more compelling. In a multinational study, which the Hadassah Medical Organization Diabetes Unit helped to design, researchers discovered that dapagliflozin not only proved to have a good safety profile, but also to lower the rate of cardiovascular death from and hospitalization for heart failure.

The researchers explain that because diabetics are at risk for both cardiovascular disease caused by plaque build-up inside their arteries (atherosclerosis), as well as heart failure, “the importance of determining diabetes therapies that are not only safe but also effective in reducing cardiovascular risk is paramount.”  

Entitled DECLARE-TIMI 58, the phase 3, double-blind, placebo-controlled study, highlighted in the January 24, 2019 issue of The New England Journal of Medicine, was conducted at 882 sites in 33 countries. It involved 17,160 patients with type 2 diabetes, 10,186 of whom did not have atherosclerotic cardiovascular disease, but did have multiple risk factors for the disease. It was designed collaboratively by the Thrombolysis in Myocardia Infarction (TIMI) Study Group, the Hadassah Medical Organization, the trial executive committee, and AstraZeneca, its sponsor. Prof. Itamar Raz, former head of Hadassah’s Diabetes Unit, and endocrinologists Dr. Ofri Mosenzon and Dr. Avivit Cahn were the Hadassah physicians involved in conducting the study. 

The primary safety outcome explored was a composite of major adverse cardiovascular events (MACE), including cardiovascular death, myocardial infarction, or ischemic stroke. Dapagliflozin was not any less safe than the placebo. The two primary efficacy outcomes were whether the drug lowered MACE or cardiovascular death from or hospitalization for heart failure. While dapagliflozin did not bring about a lower rate of MACE in either group of patients, it did result in a lower rate of cardiovascular death and hospitalization for heart failure. This lower rate, the researchers report, “was consistent across multiple subgroups, which shows that dapagliflozin prevented cardiovascular events, particularly hospitalization for heart failure, in a broad range of patients, regardless of a history of atherosclerotic cardiovascular disease or heart failure.”

In addition, it should be noted that dapagliflozin has been shown to have a robust protective effect on the kidneys. “This study, along with additional studies testing the safety and efficacy of medications belonging to the family of SGLT2 inhibitors, will change the paradigm for the treatment of patients with type 2 diabetes,” comments Prof. Gil Leibowitz, head of Hadassah’s Diabetes Center.

Learn more about the Hadassah Medical Organization.

Comments

No comments yet.
First Name
Email
Comment
Enter this word:

Related Stories

alt_text

Thursday, Apr 18 2019

Hadassah Cardiac Specialist Recognized for Lifetime Achievement

Congratulations to Hadassah Medical Organization Prof. Emeritus Andre Keren upon receiving the Lifetime Achievement Award from the European Society of Cardiology’s Working Group on Myocardial and Pericardial Diseases.

READ MORE ›
alt_text

Thursday, Apr 18 2019

Hadassah’s Pollin Center Celebrates Five Years of Women’s Wellness Achievements

Longing to commemorate the early death of her daughter from cardiovascular disease, Irene Pollin established the Linda Joy Pollin Cardiovascular Wellness Center for Women at Hadassah Hospital Ein Kerem in 2013.

READ MORE ›
alt_text

Thursday, Apr 18 2019

Pre-clinical Study by Hadassah Neurologists Sheds Light on Major Player in Alzheimer’s Disease

While scientists know a vast amount about what can go wrong in a brain afflicted with Alzheimer’s disease, they also know very little about how our brains protect themselves from such injuries, reports Prof. Tamir Ben-Hur, head of the Division of Clinical Neurosciences at the Hadassah Medical Organization.

READ MORE ›
alt_text

Wednesday, Apr 17 2019

First in Israel: Hadasit Launches Medical Startup Accelerator with IBM

Hadasit, the Hadassah Medical Organization’s technology transfer company, has launched Israel’s first biotechnology hub within a medical center.

READ MORE ›

Donation Questions

donorservices@hadassah.org

(800) 928-0685

Membership Questions

membership@hadassah.org

(800) 664-5646

Missions Department

missions@hadassah.org

(800) 237-1517

Contact Us

40 Wall Street

New York, NY 10005

support@hadassah.org

More ›

Show More