Hadassah

New Lymphoma Drug, Thanks to Hadassah and Pennsylvania Physician/Scientists

Tuesday, Dec 29 2015

Nephrologist Prof. Michal Dranitzki Elhalel and Pennsylvania Pathologist Prof. Mark L. Tykocinski.

KAHR-102, a new immunotherapy drug to treat lymphoma, based on technology developed by Hadassah Medical Center Nephrologist Prof. Michal Dranitzki Elhalel and Pennsylvania Pathologist Prof. Mark L. Tykocinski, will begin clinical trials in mid-2016 at Hadassah, Tel-Hashomer, and Ichilov (Tel Aviv) medical centers.

Prof. Dranitzki Elhalel, now head of Nephrology at Hadassah, explored possible applications for the fusion protein CTLA4-Fast while a research fellow in 2000 at the University of Pennsylvania laboratory of Prof. Mark L. Tykocinski, who invented CTLA4, now known as KAHR-102. Prof. Tykocinski, then head of the Department of Pathology and Laboratory Medicine at the University of Pennsylvania, is now Dean of the Jefferson Medical School, Philadelphia, PA and Provost and Executive Vice President for Academic Affairs of the Thomas Jefferson University.

When she returned to Hadassah, Prof. Dranitzki Elhalel, with Prof. Tykocinski's encouragement,  continued to study this potential drug in her own laboratory, as well as other fusion proteins of the same class. KAHR-102, she explains,”is a fusion of portions of two naturally occurring human proteins into one chimeric protein with two functional ends. These two functional ends can bring synergistic effects, leading to highly targeted death of specific cells that can bind both sides of the protein, like malignant lymphoma cells.” She adds: “Interestingly, we found out that the resulting fusion protein has a unique structure that strongly increases its potency while conserving its specificity to the malignant lymphoma cells.”

KAHR medical Ltd., based on Prof. Tykocinski's patents, was established in 2007 by Hadasit, Hadassah’s technology transfer company. Prof. Tykocinski is Chair of the Scientific Clinical Advisory Board and Prof. Dranitzki Elhalel serves as KAHR’a Chief Scientist. Prof. Arnold Freedman, head of the Lymphoma Program at Dana Farber Cancer Institute, Boston, has recently joined KAHR’s Scientific Advisory Board.

The KAHR-102 study protocol was recently approved by the Israeli regulatory authorities, clearing the way for the clinical trial to begin mid-2016. The drug company, specializing in cancer and autoimmune disease drugs, reports that its products “form a new generation of biological drugs with great diversity and superior efficacy for the treatment of multiple cancer and autoimmune diseases.”

Comments

From: janine on February 14, 2016
can you have me? I have lymphoma,
From: janine on February 14, 2016
As a person living with lymphoma, I an excited to learn more. Can you help me?
From: Muriel on February 5, 2016
As a person living with lymphoma, I am very anxious to learn the results of the clinical trial. It sounds promising and I really hope it is effective.
First Name
Email
Comment
Enter this word:

Related Stories

alt_text

Wednesday, Feb 22 2017

Hadassah Medical Organization Performs Israel’s First Spina Bifida Fetal Surgery To Lessen Crippling Spinal Damage

History was made at Hadassah Ein Kerem Hospital in Jerusalem on Thursday, February 9 when a team of Israeli surgeons successfully operated on a 5-month-old fetus using a new procedure that only three doctors in the world can perform, to alleviate some of the crippling effects of Spina Bifida.

READ MORE ›
alt_text

Tuesday, Feb 21 2017

Hadassah Cardiologists Publicize Israel’s Dramatic Decrease in Cardiovascular Death

Prof. Emeritus Mervyn Gotsman and Prof. Israel Gotsman of Hadassah Hospital’s Heart Institute have coauthored an article which appeared in the European Heart Journal, highlighting the fact that “between 1998 and 2012, mortality from cardiovascular disease in Israel has fallen from 162 to 80 per 100,000 residents--a decrease of 50 percent.”

READ MORE ›
alt_text

Tuesday, Feb 21 2017

Ambassadors of Health for Heart Smart Living: A Unique Hadassah Program

Knowing that the workplace is where people spend vast quantities of time, the Hadassah Medical Organization’s Linda Joy Pollin Cardiovascular Wellness Center for Women launched a unique course to encourage heart healthy living—during the work day.

READ MORE ›
alt_text

Tuesday, Feb 21 2017

Hadassah Brings Health Empowerment to East Jerusalem

The increased incidence of diabetes in the Arab community, as well as the 60 percent higher rate of cardiovascular mortality among Arab women led the Hadassah Medical Organization’s Linda Joy Pollin Cardiovascular Wellness Center for Women to develop a community-based program to cultivate leadership that embraces and advocates for healthy living which will reduce diabetes in this population.

READ MORE ›

Donation Questions

donorservices@hadassah.org

(800) 928-0685

Membership Questions

membership@hadassah.org

(800) 664-5646

Missions Department

missions@hadassah.org

(800) 237-1517

Contact Us

40 Wall Street

New York, NY 10005

support@hadassah.org

More ›

Show More