Hadassah

Granalix BioTechnologies Introduces Food Additive to Protect Against Neurodegenerative Disease

Monday, Nov 14 2016

Prof. Ruth Gabizon with neurology research colleagues.

Granalix BioTechnologies, whose founder and Chief Executive Officer is Hadassah Medical Organization Experimental Neurologist Prof. Ruth Gabizon, has launched a food supplement containing pomegranate oil that has proven to protect against neurodegenerative diseases in pre-clinical models.

Called GranaGard™, the supplement is a submicron Pomegranate Seed Oil (PSO) emulsion, and is an innovative formulation of one of the strongest natural antioxidants, Punicic acid (an Omega 5 lipid). The patented formulation has been shown to delay disease onset and prevent neuronal death in a model of genetic prion disease (a neurodegenerative disease caused by a mutation that leads to misfolded prion proteins which, in turn, kill off normal brain cells). The formulation also has been shown to reduce disease burden in a mouse model of Multiple Sclerosis. In both models, there was no evidence of toxicity after long-term administration.

As Prof. Gabizon explains: "Reactive oxygen species (ROS) are chemically active molecules that can lead to significant damage to cells, particularly in the central nervous system (CNS). It is therefore widely accepted that this chemical agent contributes to chronic inflammation and neurodegenerative diseases. While antioxidants that can counteract ROS are ubiquitously present in a healthy human diet, their activity is limited by chemical degradation, poor bioavailability, reduced distribution to the CNS, and sub-pharmacological doses.”

To overcome these limitations, Prof. Gabizon relates, she and her research team created GranaGard. “In addition to its protective role in subjects at risk of developing neurodegenerative conditions,” she says, “GranaGard is expected to be effective for general neurological well-being for the larger public.” 

Company spokespeople explain that the PSO submicron droplets have the advantage that the nanoformulation may avoid the first passage of the oil through the liver, thereby enhancing the availability of the droplets to other organs such as the CNS where it is then able to enter the brain and protect membrane lipids from ROS attacks that occur as a result of both every-day efforts and pathological events.

Granalix BioTechnologies focuses on developing science-based novel formulations of natural antioxidants that can be used to prevent and treat neurodegenerative conditions. The Company was established in 2014 by Prof. Gabizon and Prof. Shlomo Magdassi of the Casali Center for Applied Chemistry, the Institute of Chemistry, and the Center for Nanoscience and Nanotechnology at the Hebrew University. It is a spinoff of the Hebrew University’s technology transfer company, Yissum, and Hadasit, Hadassah’s technology transfer company.

Comments

No comments yet.
First Name
Email
Comment
Enter this word:

Related Stories

alt_text

Monday, Dec 10 2018

A Nurses Council Celebration in Israel: The Milestone Mission

We were honored to meet so many dynamic Hadassah nurses, some longtime and some new members--all of us excited to be together to celebrate the 100th anniversaries of the Hadassah Medical Organization, the Henrietta Szold Hadasssah-Hebrew University Nursing School and HMO's Department of Ophthalmology. And Israel's 70th

READ MORE ›
alt_text

Wednesday, Dec 5 2018

Ending the Violence Against Women: Hadassah Staff Joins Nationwide Protests

On December 4, employees from both Hadassah Hospital Ein Kerem and Hadassah Hospital Mount Scopus rallied to end violence against women. “Together we will banish the darkness and return the light to all women,” read banners held by the participants.

READ MORE ›
alt_text

Wednesday, Dec 5 2018

Prof. Chowers’ Long and Meaningful Hadassah Connections

Sophie Szold, mother of Hadassah founder Henrietta, wept when she saw children with flies in their eyes on their maiden trip to pre-state Israel in 1909. Those children had trachoma, endemic in the Middle East in those days.

READ MORE ›
alt_text

Tuesday, Dec 4 2018

15 Years of Fighting HIV/AIDS: Hadassah Joins Bipartisan White House Event

Hadassah was represented at the invitation-only event by Judith Levy, Co-Chair of the Hadassah Nurses Council, who joined more than 100 others gathered to recognize the huge strides made in HIV/AIDS prevention and treatment, thanks in part to government partnerships with faith groups and nonprofit organizations.

READ MORE ›

Donation Questions

donorservices@hadassah.org

(800) 928-0685

Membership Questions

membership@hadassah.org

(800) 664-5646

Missions Department

missions@hadassah.org

(800) 237-1517

Contact Us

40 Wall Street

New York, NY 10005

support@hadassah.org

More ›

Show More