Hadassah

Placental Stem Cells Prove Successful in Bringing Little Girl to Recovery at Hadassah

Tuesday, May 15 2012

Using placental mesenchymal stem cells--which proved effective in pre-clinical trials--physicians at the Hadassah University Medical Center rescued the life of a seven-year-old Romanian girl whose two bone marrow transplants were not triggering the repair needed to save her life.

“B” was suffering from severe aplastic anemia, a disorder where the bone marrow does not produce sufficient new cells to replenish the blood. For the last 10 months, she had been hospitalized at Hadassah in critical condition. While her body accepted the two transplants from two different donors, the donated bone marrow was unsuccessful in getting her body to take over the replenishment process and produce new red blood cells. Prof. Reuven Or, head of the Sidney Weisner Department of Bone Marrow Transplantation and Cancer Immunology, decided to speak with Prof. Rafi Gorodetsky, Director of Hadassah’s Biotechnology and Radiobiology Laboratory in the Sharrett Institute of Oncology, who was conducting stem cell research sponsored by Pluristem Therapeutics, an Israeli bio-tech company which develops placental mesenchymal cells.  Prof. Gorodetsky's pre-clinical trial showed success in treating radiated mice with the Pluristem cells. (See ”Placental Cells Found to Have Potential to Mitigate Acute Radiation Syndrome,” in www.hadassah.org/hmedicine, October 2011.)

After receiving the approvals of Hadassah's Helsinki Committee and Israel’s Ministry of Health, Hadassah’s physicians gave “B” two shots of the Pluristem cells, injecting them into her thigh muscle. The recovery was so significant that “B” was able to leave the hospital.

"This is a moment every physician and researcher waits for," says Prof. Or. "We now have a new tool and I always prefer to use biological substance over chemical components." Prof. Or cautions, however, that this is only one single case and 
the treatment still requires full scientific exploration and validation. Scientists at Pluristem and Prof. Or will now discuss “next steps” and how to widen the scope of their studies.

“Whatever happens next,” comments Ron Krumer, Director of Hadassah’s External Relations Department, “we can enjoy another story of life saving at Hadassah--a combination of the ingenuity of an Israeli biotech firm, Hadassah research, and Hadassah clinical excellence.”

Comments

No comments yet.
First Name
Email
Comment
Enter this word:

Related Stories

alt_text

Thursday, Jan 11 2018

Hadassah’s Heart Institute: Innovation at the Forefront

Prof. Chaim Lotan, head of the Hadassah Medical Organization’s Heart Institute, has made it a personal objective to foster innovation in cardiovascular technology.

READ MORE ›
alt_text

Thursday, Jan 11 2018

Medical Clown Nehama’s Blog, Chapter Five: Out of Love

“I met Masha in the surgery waiting room at Hadassah Hospital Ein Kerem,” says Medical Clown Shira, as she proceeds to convey this story: Masha is a three-year-old girl who lives in Russia. Every three months, she comes to Hadassah for an oncological examination under full anesthesia.

READ MORE ›
alt_text

Wednesday, Jan 10 2018

Drug Company Collaborates with Hadassah Liver Specialist in Fighting Liver Disease

Dr. Rifaat Safadi, head of the Hadassah Medical Organization’s Liver Unit, in its Institute of Gastroenterology and Liver Diseases, is collaborating with Can-Fite BioPharma Ltd. to explore further the healing effects of a new drug that has proven in preclinical studies to mitigate inflammatory diseases of the liver, such as NASH (non-alcoholic steatohepatitis).

READ MORE ›
alt_text

Wednesday, Jan 10 2018

Bedridden Teen Walks Again, Thanks to First-in-Israel Complex Spinal Surgery at Hadassah

Yusef Rabaya, age 19, spent most of his life in bed at home in Jenin. Born with cerebral palsy (CP), he could sit only if he was propped up. Standing was excruciating and dangerous--and could cause permanent paralysis.

READ MORE ›

Donation Questions

donorservices@hadassah.org

(800) 928-0685

Membership Questions

membership@hadassah.org

(800) 664-5646

Missions Department

missions@hadassah.org

(800) 237-1517

Contact Us

40 Wall Street

New York, NY 10005

support@hadassah.org

More ›

Show More