Hadassah

Pro-Tumor White Blood Cells Discovered at Hadassah

Tuesday, Feb 3 2015

Researchers at the Hadassah Medical Organization and Hebrew University have found that the most common form of white blood cells, called neutrophils, contain at least three distinct subtypes. Some fight the development of cancer, while others provide a hospitable environment for their growth.

The research findings could lead to new cancer-fighting therapies that seek to boost the anti-tumor neutrophils while limiting the proliferation of pro-tumor neutrophils.

In the last decade new approaches to cancer have involved activating the patient’s immune system against cancer cells, while not harming nearby healthy cells. Recently, however, researchers have discovered that there are healthy cells which surround the tumor that play an important role in enhancing cancer development. Thus, while neutrophils, which comprise between 50-70 percent of all white blood cells, are traditionally associated with fighting infections, accumulating data suggest they also play an important role in tumor biology. The Hadassah-Hebrew University scientists, working with mouse tumors and human blood samples, found that in early stages of the disease, tumor-limiting neutrophils prevail, but as cancer progresses, the tumor-promoting neutrophil subpopulation becomes dominant. As the authors explain:

“We identified a heterogeneous subset of low-density neutrophils (LDNs) that appear transiently in self-resolving inflammation, but accumulate continuously with cancer progression. LDNs display impaired neutrophil function and immunosuppressive properties, characteristics that are in stark contrast to those of mature, high-density neutrophils (HDNs). Proper understanding of the effect of tumors on neutrophils, as well as the way these cells support or fight cancer, could help us develop strategies to direct the immune system against the tumor, and potentially improve cancer treatment in general and immunotherapy in particular."

The research study, led by Dr. Zvi Fridlender, at the Hadassah-Hebrew University Medical Center’s Institute of Pulmonary Medicine, and Dr. Zvika Granot, at the Hebrew University’s Institute for Medical Research Israel-Canada (IMRIC) in the Faculty of Medicine, is highlighted in "Phenotypic Diversity and Plasticity in Circulating Neutrophil Subpopulations in Cancer" in the January 22, 2015 on-line issue of Cell Reports.

Comments

No comments yet.
First Name
Email
Comment
Enter this word:

Related Stories

alt_text

Tuesday, Jun 20 2017

Send in the Clowns: A Hadassah UK Dispatch

This week Hadassah UK (HUK) brought in one of the Hadassah Medical Organization's best and more unusual, head medical clown David Barashi (DuSH).

READ MORE ›
alt_text

Friday, Jun 16 2017

Hadassah’s Director General Receives Honorary PhD from Cyprus Medical School

For sharing his knowledge and experience with senior officials in the Cyprus medical system, Prof. Zeev Rotstein, Director General of the Hadassah Medical Organization, was awarded an honorary PhD from the St. George University of London’s Medical Program at the University of Nicosia Medical School in Cyprus.

READ MORE ›
alt_text

Thursday, Jun 8 2017

Hadassah Doctors Discover Bullet
in 12-Year-Old’s Arm

Muhammad Baduan, age 12, had been experiencing pain in his arm on and off for months. Hadassah Hospital Ein Kerem Emergency Room physicians put an end to the boy’s pain when they solved the mystery: Muhammad had a 22-millimeter bullet hidden in that arm--a bullet that had been shot into the air as part of a post-wedding ceremony celebration.

READ MORE ›
alt_text

Monday, Jun 5 2017

Hadassah Cutting-Edge Neuropsychiatrist Keynotes Alzheimer’s Conference

“The key is to give medicines much earlier--before the brain material has been destroyed by Alzheimer’s disease,” Dr. Shahar Arzy, head of the Hadassah Medical Organization’s Computational Neuropsychiatry Laboratory, told his audience at the Alzheimer’s Foundation of America (AFA)’s New York Educational Conference on May 5, 2017.

READ MORE ›

Donation Questions

donorservices@hadassah.org

(800) 928-0685

Membership Questions

membership@hadassah.org

(800) 664-5646

Missions Department

missions@hadassah.org

(800) 237-1517

Contact Us

40 Wall Street

New York, NY 10005

support@hadassah.org

More ›

Show More