Hadassah

Study by Renowned Hadassah Neuropsychiatrist Featured in The Lancet

Thursday, Sep 7 2017

The work of Dr. Shahar Arzy, head of the Hadassah Medical Organization’s Neuropsychiatry Clinic and the Hadassah-Hebrew University Computational Neuropsychiatry Laboratory, is featured in the September 4, 2017 issue of The Lancet Psychiatry.

Dr. Arzy’s study, in collaboration with colleagues in Berlin, Germany, involved 43 patients with a particular form of severe brain inflammation. Using functional magnetic resonance imaging (MRI), the research team was able to witness changes in the connections within the patients’ brain networks.

Individuals who suffer from this particular form of brain inflammation called “anti-NMDA receptor encephalitis,” exhibit severe neuropsychiatric symptoms, including psychosis, memory deficits, and movement disorders. How the specific dysfunction leads to these clinical symptoms, however, is not understood. Do the symptoms arise from an impairment in specific brain regions? Do they arise from the interactions between these impaired regions?  The answers remain elusive.

In this study, Dr. Arzy’s research team observed 43 age and sex-matched healthy individuals, along with the 43 who had encephalitis. Although structural MRI proved normal in 31 (72 percent) of the 43 patients, the researchers report that they observed “widespread alterations of functional connectivity” and that these alterations correlated with what they saw clinically. The authors explain that “memory impairment correlated with hippocampal and medial-temporal-lobe network connectivity, whereas schizophrenia-like symptoms were associated with functional connectivity changes in frontoparietal networks.”

As the authors summarize: “This study reveals a characteristic pattern of whole-brain functional connectivity alterations in anti-NMDAR encephalitis that is well suited to explain the major clinical symptoms of the disorder.”  They also note that their findings could be similarly relevant for other neuropsychiatric disorders, such as schizophrenia.

Comments

No comments yet.
First Name
Email
Comment
Enter this word:

Related Stories

alt_text

Friday, Aug 17 2018

Hadassah Mourns the Loss of Aretha Franklin and Urges Greater Awareness of Diagnosis and Treatment of Pancreatic Cancer

Sadly, the “queen of soul” Aretha Franklin passed away yesterday at age 76, due to an advanced pancreatic neuroendocrine tumor (pancreatic NET or PNET).

READ MORE ›
alt_text

Wednesday, Aug 15 2018

Hadassah Hospital’s Bone Marrow Transplant Department Receives International Acclaim

In a first for Israel, Hadassah Medical Organization’s Bone Marrow Transplantation and Cancer Immunotherapy Department has recently received full accreditation by the Joint Accreditation Committee ISCT-EUROPE & EBMT (JACIE), Europe’s only official accreditation body in the field.

READ MORE ›
alt_text

Tuesday, Aug 14 2018

Hadassah Hospital Helps Educate Mikvah Attendants To Bolster Women’s Health

After a woman emerges from the ritual bath (mikveh) and wraps herself in a towel, says mikveh attendant Daniella Salomon, “I keep an eye out” for anything unusual.

READ MORE ›
alt_text

Tuesday, Aug 7 2018

American Medical Attaché and Consulate Nurse Tour Hadassah Hospital Ein Kerem

Jennifer Kmiecinski, Medical Attaché to the Consulate General of the United States in Israel, visited Hadassah Hospital Ein Kerem earlier this month to assess the level of health care available to American personnel serving in Israel.

READ MORE ›

Donation Questions

donorservices@hadassah.org

(800) 928-0685

Membership Questions

membership@hadassah.org

(800) 664-5646

Missions Department

missions@hadassah.org

(800) 237-1517

Contact Us

40 Wall Street

New York, NY 10005

support@hadassah.org

More ›

Show More