Hadassah

BrainStorm Stem Cell Therapy for ALS is Fast-Tracked to New Phase

Thursday, Jan 24 2013

The ALS PhaseI/II safety trial of Brainstorm Cell Therapeutics' NurOwn stem cell therapy has been fast tracked to a Phase IIa dose-escalating trial by Israel's Ministry of Health and will be launched "immediately" at the Hadassah Medical Center, reports this leading developer of adult stem cell technologies for neurodegenerative diseases.

Prof. Dimitrios Karussis, Principal Investigator of BrainStorm's Phase I/II trial and head of the Multiple Sclerosis Center at Hadassah, commented: "Based on the positive results we have seen for the first 12 patients, we are eager to begin the next stage of clinical testing, and are delighted that the Ministry of Health has given us the green light to proceed to Phase IIa."

"Acceleration to Phase IIa will save us critical time, enabling us to proceed much more quickly with achieving our goal of developing an effective treatment for ALS," said Dr. Adrian Harel, BrainStorm's Chief Executive Officer.

In the Phase IIa trial, the second group of 12 patients from the initial cohort of 24 will receive combined intramuscular and intrathecal administration of NurOwn cells in three cohorts, with increasing doses. The study participants, who have already been recruited, will be followed for three to six months after transplantation.

BrainStorm plans to expand its clinical development to the United States in 2013, pending approval by the Food and Drug Administration. The company has entered into a Memorandum of Understanding with the University of Massachusetts Medical School and Massachusetts General Hospital to begin ALS human clinical trials at these medical facilities.

BrainStorm's NurOwn is a first-of-its-kind adult stem cell therapy for the treatment of neurodegenerative diseases derived from autologous bone marrow cells.

Related Stories

alt_text

Monday, Sep 16 2019

Hadassah Australia Will Help Ethiopian Israelis Achieve Their Dream

Barely 11 percent of Ethiopian Jewish students attend university in Israel, as compared to 42 percent of their counterparts in the general population.

READ MORE ›
alt_text

Friday, Sep 6 2019

An Oasis of Peace

In the Jerusalem Post, Hadassah President Ellen Hershkin writes about Middle East peace, shared society and dignity for all.

READ MORE ›
alt_text

Friday, Sep 6 2019

New, Larger Pediatric Bone Marrow Transplant Unit Opens at Hadassah

With a $4.75-million grant from The Leona M. and Harry B. Helmsley Charitable Trust, the Hadassah Medical Organization has opened a new pediatric bone marrow transplantation...

READ MORE ›
alt_text

Friday, Sep 6 2019

Creating an Exceptional Bar Mitzvah Experience

Thirty members of the Moises Jafif family from Mexico, along with their friends, came to Israel to celebrate the Bar Mitzvah of Jak Jafif at the Kotel (the western wall of the ancient Temple Mount).

READ MORE ›
SUPPORT HADASSAH HOSPITALS

Learn more about the Hadassah Medical Organization.

Donation Questions

donorservices@hadassah.org

(800) 928-0685

Membership Questions

membership@hadassah.org

(800) 664-5646

Missions Department

missions@hadassah.org

(800) 237-1517

Contact Us

40 Wall Street

New York, NY 10005

support@hadassah.org

More ›

Show More