Hadassah

Conquering Brain Tumors at the Molecular Level

Monday, Dec 9 2013

For Regina Golan-Gerstl, a postdoctoral fellow at the Hadassah-Hebrew University School of Medicine, the fight against brain cancer has been close-up and personal: her mother died of the disease. She has now identified a genetic protein that is directly implicated in the development of the most prevalent brain cancer--glioblastoma.

Initially working in the specialty of pulmonology with Senior Hadassah Prof. Raphael Breuer, researching how cells communicate with one another, Dr. Golan-Gerstl switched to studying brain cancer when her mother became ill.

There is a mechanism called "splicing," she says, where elements of RNA (ribonucleic acid) are cut and recombined like sections of movie film. When a person is sick, Dr. Golan-Gerstl explains, the splicing mechanism doesn't work in the same way. An alternative splicing occurs, thanks to a genetic protein which becomes an activist in the development of cancer. She and her team have found that when the action of this gene is turned off, tumors in mice decrease in size. Dr. Golan-Gerstl adds that their first success has been with brain cancer.

Further investigation is taking place with other metastatic cancers, such as breast cancer. Tackling the problem with colleagues in Hadassah's Neuro-Oncology Department, Dr. Golan-Gerstl relates that they are "working on shutting it down at a molecular level."

Michael Klipper, Chair of Voices Against Brain Cancer, an organization dedicated to brain cancer research and advocacy, comments on the organization's website that "this discovery is comforting for those who are and who have been affected by this horrible disease. For one, it shows them that there are dedicated scientists and researchers who are working around the clock to put an end to this horrible disease. And two, it gives them hope that there actually will one day be a cure for brain cancer."

Related Stories

alt_text

Tuesday, Aug 11 2020

Hadassah Physician-Scientists Are Showcased at Global Press Conference

At an August 6 press conference hosted by Hadassah International, four of the 19 Hadassah Medical Organization physician-scientists who received research grants this year from the Israel Science Foundation (ISF) presented their latest work.

READ MORE ›
alt_text

Tuesday, Aug 4 2020

Kidney Donation Keeps on Giving: A Hadassah Story

It is said that one good turn leads to another. Two years ago, Hadassah clinical psychologist Benny Kashany altruistically donated a kidney to a total stranger.

READ MORE ›
alt_text

Monday, Aug 3 2020

Hadassah Treats 9-Year-Old With Mysterious Bullet Lodged in His Brain

Last Friday, on the Muslim holiday of Eid al-Adha, in the Jerusalem neighborhood of Ras al-Amud, a stray bullet hit a 9-year-old boy in the head.

READ MORE ›
alt_text

Monday, Aug 3 2020

Hadassah Physician Turns to SodaStream to Ease COVID-19 Patients’ Breathing

How’s this for thinking outside of the box? Seeking a better device than the invasive ventilator to ease COVID-19 patients’ breathing difficulties...

READ MORE ›

Donation Questions

donorservices@hadassah.org

(800) 928-0685

Membership Questions

membership@hadassah.org

(800) 664-5646

Israel Travel

israeltravel@hadassah.org

(800) 237-1517

Contact Us

40 Wall Street

New York, NY 10005

support@hadassah.org

More ›

Show More