Hadassah

Hadassah and Boston Cardiologists Identify Factor Which Exacerbates Heart Failure

Thursday, Sep 27 2012

In a series of experiments, Dr. Ronen Beeri, Director of the Cardiovascular Research Center at the Hadassah Medical Center, and Dr. Robert Levine, Senior Physician at Massachusetts General Hospital in Boston, have demonstrated that mitral regurgitation augments the remodeling process occurring after a myocardial infraction which, in turn, exacerbates further heart failure.

They have also discovered that repairing the mitral regurgitation early enough may reverse these deleterious processes, while delayed repair may not. The two physicians have now begun to explore the cellular processes which cause the individual cells to fail. In what may hold promise for the future, they have utilized gene therapy techniques in a sheep model of heart failure to implant a gene for the Sarcoplasmic reticulum Ca (+2)-ATPase ( SERCA2a), which controls a key process in the cell's calcium signaling. The sheep which underwent gene therapy had upregulated levels of SERCA2a, which led to better function and lesser remodeling. They exhibited improved contractility, smaller heart volumes, and activation of cellular pathways that lead to better heart compensation.

Related Stories

alt_text

Thursday, Oct 10 2019

Hadassah Leads International Study on Changing Intensive Care Practices on End-of-Life Decisions

Intensive care teams the world over deal daily with matters of life and death.

READ MORE ›
alt_text

Thursday, Oct 10 2019

Devastating Diagnosis, But Options for Optimism

A 26-year-old woman we can call Miriam is a wife and a mother, with a lively toddler. One recent day, she noticed a small lump in her breast.

READ MORE ›
alt_text

Tuesday, Oct 8 2019

From the Heart: Reflections Upon Retirement

Prof. Chaim Lotan has just completed two decades as director of Hadassah’s Heart Institute...

READ MORE ›
alt_text

Tuesday, Oct 8 2019

Intervening at the End of Life: What Has Changed?

On Yom Kippur, the Day of Atonement, as Jews the world over confront the uncertainty of their personal futures and chant the somber holiday prayer Unetaneh Tokef...

READ MORE ›
SUPPORT HADASSAH HOSPITALS

Learn more about the Hadassah Medical Organization.

Donation Questions

donorservices@hadassah.org

(800) 928-0685

Membership Questions

membership@hadassah.org

(800) 664-5646

Missions Department

missions@hadassah.org

(800) 237-1517

Contact Us

40 Wall Street

New York, NY 10005

support@hadassah.org

More ›

Show More