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Stem Cell Trial at Hadassah Reveals Significant Positive Results for ALS Patients

Thursday, Jan 8 2015

Israel's BrainStorm Cell Therapeutics has reported that final results of its clinical trial conducted at the Hadassah Medical Organization using adult stem cells to treat amyotrophic lateral sclerosis (ALS) indicate that most patients experienced a slowing of their disease's progression.

Principal Investigator Prof. Dimitrios Karussis, Senior Neurologist at the Hadassah Medical Center and Director of its Multiple Sclerosis Center, presented the interim results of this Phase IIa study at the 2014 Joint Congress of European Neurology in Istanbul. Prof. Karussis and Hadassah’s team, including Prof. Tamir Ben-Hur, Chair of Neurology, started work on clinical application of stem cell treatment in 2007 and published their results in 2010. “We then partnered with BrainStorm,” Prof. Karussis relates, “which combined the cells with hormones, including growth factors, to improve the performance outcomes.” It was Prof. Ben-Hur’s pioneering research, however, that laid the scientific foundation for the current use of stem cells to inhibit brain inflammation and protect the brain in treating multiple sclerosis. These principles of using stem cells for therapy were then expanded for additional conditions, such as ALS.

A single dose of the stem cell treatment called NurOwn was administered in a mid-stage phase IIa trial in 14 patients with ALS, also known as Lou Gehrig's Disease. “Nearly all subjects in this study experienced clinical benefit from treatment with NurOwn," the company spokesman said. “Of the 12 patients with three or more months of follow-up, 92 percent experienced an improvement in regard to the progression of their disease.” Furthermore, BrainStorm reports, NurOwn had a strong effect on the rate of decline in lung function.

"We observed individuals with prolonged stabilization and even improvements in function, and this was achieved with just a single dose of NurOwn," commented BrainStorm Chief Executive Tony Fiorino.

BrainStorm, which is also conducting clinical trials at three sites in the United States, plans to initiate a study in the next few months to see if the results can be amplified with repeated doses.

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